Solenne contains ten clinically selected ingredients across six coordinated pathways. 

• Energy Production: Riboflavin (400 mg) and Biotin (30 mcg). 
• Acetylcholine Support: Citicoline (250 mg). 
• Stress Management and Calm Focus: Ashwagandha KSM-66 (300 mg, standardized to 5% withanolides) and L-Theanine (100 mg). 
• Neuroplasticity and Cognitive Resilience: Lion's Mane Fruiting Body Extract (250 mg, 30% extract) and Zinc Bisglycinate (10 mg). 
• Mood, Sleep, and Cognition: Saffron Extract (30 mg, standardized to 2% Safranals and 4 - 6% Crocins). 
• Hormone Signaling and Metabolism: Genistein (60 mg, from Sophora japonica) and DIM (100 mg). 

Full ingredient details and dosages are available on the product page.

⚠️ HRT Compatibility: Important Notice 

Solenne contains genistein, a naturally occurring phytoestrogen sourced from Sophora japonica that acts on estrogen receptors. If you are currently taking HRT, please consult your prescribing doctor before adding Solenne to your regimen, as genistein may interact with your HRT. A genistein-free version for women on HRT is being explored for a future release. 

Most menopause supplements are designed around hot flushes and night sweats, the most visible physical symptoms. Cognitive symptoms are typically listed as an afterthought, supported by token ingredient inclusions at sub-therapeutic doses. Solenne was designed from the ground up to address the neuroscience of cognitive decline in menopause. Every ingredient is included at a clinically relevant dose, for a documented mechanistic reason, with full transparency on the label. There are no proprietary blends, no hidden dosages, and no ingredients included for marketing appeal rather than clinical value.

Solenne works at multiple speeds, depending on which ingredients and mechanisms are most relevant to you.
Day 1: Within one to five hours of your first dose, Citicoline begins increasing brain energy and supporting focus. L-Theanine takes the edge off daily stress and mental tension within the first hour, creating a calm, focused mental state. Many women notice something tangible on day one.


Week 1: Sleep quality, evening calm, and stress reactivity begin to shift as Ashwagandha, L-Theanine, and Saffron start working together. Citicoline-driven attention starts to feel more readily available.


Weeks 2 to 4: Most women describe the clearest shift in this window. Reduced brain fog, steadier mood, easier word retrieval, and fewer moments of mid-sentence word loss. Saffron's mood signal begins to consolidate by week four. Citicoline's structural membrane benefits become measurable between weeks two and four.


Weeks 4 to 8: The peak clinical window across the full formula. Citicoline's attention benefits are measurable at 28 days. Saffron mood benefits consolidate at four to six weeks. Ashwagandha, cortisol, and stress benefits peak at eight weeks. DIM estrogen metabolite shifts become measurable at four weeks. Genistein's estrogenic benefits, including hot flash reduction, stabilize over four to twelve weeks.


Weeks 8 to 16: Ashwagandha's hormonal estrogen-supporting effects build progressively. Lion's Mane, working in partnership with Ashwagandha and Saffron, supports long-term memory consolidation, neuroplasticity, and cognitive resilience. Continued Citicoline-driven gains in attention and processing speed.


3 months and beyond: Riboflavin's energy-supporting effect reaches maximum benefit around the three-month mark. Genistein's bone density support builds over six to twelve months. Lion's Mane continues supporting the long-term structural cognitive backbone of the formula. This is the horizon where the deepest neuroprotective and hormonal benefits occur. We recommend a minimum 90-day commitment to fully assess Solenne's impact. Take it every morning with a fat-containing breakfast and do not skip days.

Take 3 capsules every morning with a fat-containing breakfast. Healthy fats support the absorption of key ingredients in the formula, so pairing Solenne with eggs, avocado, nuts, or any meal cooked in olive oil will get the best results. Take it at the same time each morning to build a consistent routine; that consistency is what allows the formula to work.

Yes. The Brain Brownout model is grounded in published PET neuroimaging research that documents measurable reductions in brain glucose metabolism during the menopausal transition. The mechanisms underpinning each of the ten ingredients in the Solenne formula are supported by peer-reviewed clinical literature.  We publish our sources, and they are available in The Science section of this website. We do not make claims we cannot substantiate, and we do not cite research we have not read.

Standard US delivery: 2-Day Delivery: 2 business days. Express delivery: Next Day Delivery: next business day. You will receive a tracking confirmation email as soon as your order has been dispatched.

We offer four delivery options across the United States, with costs calculated at checkout based on your location:

• Standard Delivery: from $6.29
• Priority Delivery: from $9.91
• 2-Day Delivery: from $12.91
• Next Day Delivery: from $19.27

All orders are fully tracked. You will receive a confirmation email with your tracking details as soon as your order has been dispatched.

We process orders quickly to ensure fast dispatch. If you need to make a change or cancel, please contact us at [email address] as soon as possible. We will do our best to accommodate your request, but we cannot guarantee changes can be made once an order has entered the fulfillment process.

Yes. You can subscribe to receive Solenne on a 30-day or 90-day schedule. A 30-day subscription saves you 20%. A 90-day subscription is buy 2 get 1 free, saving you 33%. Cancel or pause anytime with no penalties. 

To initiate a return, please contact us at [email address] with your order number and reason for return. We will send you return instructions within one business day. Please do not return items without contacting us first.

Once we have received and processed your return, your refund will be issued to your original payment method within [X-X] business days. You will receive a confirmation email when the refund has been processed.